Cholecyctokinin And Panic Disorder

Cholecyctokinin and panic ail Cholecyctokinin is a neuropeptide found in the GI system and brain. Research has shown that it has various isolated severs that may conduct several important aras of human behavior, such as nociception, surfeit and anxiety. Cholecystokinin receptors located in the central nervous system (CNS) be known as CCK-B receptors, and they have high affinity for the tetrapeptide decompose CCK-4.

Anxiogenic effect of CKK-4 in humans suggested that it might be convolute in pathogenesis of panic disorder, and opened new avenues of research into biological aspects of anxiety. Further research showed increased sensitivity of panic disorder patients to CCK-4 in comparison with normal volunteers. Next, substances capable of blocking CCK-B receptors (CCK-B antagonists) were synthesized and their activeness was evaluated. One of such antagonists, L-365,260 proved to be effective in blocking CCK-4 induced panic attacks in panic disord...If you fate to get a full essay, order it on our website: OrderCustomPaper.com

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