Pathogenesis of Type 1 and Type 2 Diabetes - 2348 Words

Pathogenesis of diabetes type 1 and 2 Introduction After consumption of food, carbohydrates are broken down into glucose in the digestive system which is then absorbed in the blood causing an increase in the blood glucose levels. This rise stimulates the secretion of insulin from the pancreas beta cells which controls the blood glucose levels. Insulin also allows other cells to allow glucose into them by binding on specific cellular receptors thus facilitating the entry of glucose into the cell. Increased secretion of insulin by the pancreas and its subsequent utilization in the cells leads to low blood glucose levels which then result to decreased secretion of insulin. The production of insulin is also affected by disease which causes the dynamics of blood glucose to change when insulin production decreases, entry of glucose into the cells is inhibited which results to hyperglycemia. A similar situation occurs where the insulin secreted by the pancreas is not properly used by the target cells. Insulin secretion may also increase causing the blood sugar levels to become low which is hypoglycemia where the amount of glucose in tissue cells and muscles is higher than that in blood. Diabetes is the disease that occurs when a persons insulin levels are either too high or too low which results in imbalance in blood glucose levels. Type-1 diabetes occurs in those who produce little or no insulin at all while type-2 diabetes occurs in those who produce too high levels ofShow MoreRelatedTaking a Look at Diabetes958 Words   |  4 PagesIntroduction In the year 2013, it is estimated that 382 million people have diabetes; however, this is number will likely increase to 592 million by the year 2035. (1) Among Diabetes types, type2 DM is the most common form of diabetes affecting almost 85-90% of all people with diabetes. While older adults are usually involved, younger individuals, even children, are likely to have type2 DM. (2) It’s well known that many organs are involved to maintain glucose homeostasis including pancreas (a andRead MoreRenal Microvascular Complications Of Type 2 Diabetes Essay1105 Words   |  5 PagesMicrovascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Abstract There have been a number of manuscripts reporting on the association of complications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed throughRead MoreBiology Lab Report902 Words   |  4 Pagesfluctuation (BGF) contributes in chronic complications by promoting the dysfunction of vascular endothelium in diabetes. MicroRNA (miR)-34 family is known for its roles in the pathophysiology of diverse diseases including type 2 diabetes. However, the action of BGF on the expression of these miRs in diabetes is unknown. Herein, we aimed to investigate the effects of BGF on the pathogenesis of diabetes and the possible involvement of miR-34 family in vivo. Methods: A total of 60 Sprague-Dawley (SD) ratsRead MoreA Brief Note On The Major Micro Vascular Complication Of Type 2 Diabetes Mellitus1685 Words   |  7 PagesBackground: Diabetic nephropathy is the major micro-vascular complication of type 2 diabetes mellitus (T2DM) and is the main cause for end-stage kidney disease. In view of metabolic derangements of T2DM, we went further to investigate the role played by oxidized low density lipoprotein (ox-LDL), toll like receptor 4 (TLR4), lipocalin-2 (LCN2), and omentin-1 in DN. Patients and methods: 15 normo-albuminuria T2DM, 15 micro-albuminuria T2DM and 15 macro-albuminuria T2DM in addition to 15 healthy volunteerRead MoreNutrition Therapy On Type 2 Diabetes Mellitus862 Words   |  4 PagesNutrition Therapy in Type 2 Diabetes Mellitus Smelter et al. (2010) defines diabetes mellitus (DM) as a chronic metabolic disorder of glucose metabolism characterized by hyperglycemia. DM is etiologically divided into types 1 and 2 referring to inadequate insulin secretion and reduced insulin-driven glucose uptake in muscle cells respectively. However, the term â€Å"Non-insulin dependent diabetes mellitus† to refer to type 2 DM is no longer used because some degree of beta-cell failure leading to reducedRead MoreInvestigating The Aetiology And Pathophysiology Of Renal Microvascular Complications1094 Words   |  5 Pagescomplications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed through 2000 using the NIH PubMed Literature Search System. Inclusion criteria were that manuscripts 1) be primary peer-review research article; 2) conciselyRead MoreDiabetic Nephropathy : The Leading Cause Of Chronic Kidney Diseases Worldwide And Most Of The Affected Patients1143 Words   |  5 Pagesdiseases worldwide and most of the affected patients have T2DM. A considerable number of patients newly diagnosed with T2DM may already have developed nephropathy due to a preceding period of undiagnosed diabetes and impaired glucose tolerance [11]. According to the classification of American Diabetes Association, DN is divided into three stages, incipient nephropathy (micro-albuminuria), clinical diabetic nephropathy (macro-albuminuria) and ESRD. To diagnose those DN patients in its early stage canRead MoreReaction Paper On Type 2 Diabetes968 Words   |  4 Pagesendothelial complications in type 2 diabetes; secondly, we intended to scrutinize the possible involvement of miR-34 family members in this process. We showed that BGF exacerbated the detrimental effects associated with type 2 diabetes via possible downregulation of miR-34b/c, which represents a new potential avenue for the treatment of cardiovascular complications associated with type 2 diabetes. According to our study, the changes in weight as well as the levels of SOD, MDA, NO and ET-1 were more significantRead MoreDiabetes : The Common Chronic Disorders1737 Words   |  7 PagesINTRODUCTION: Diabetes is one of the most common chronic disorders in UK [1]. According to Silverman, more than 2.6 million people in UK are diabetic as according to data collected from GP practices and more than 5 million obese people are registered to GP practices. So One in ten people are getting treatment for obesity and one in 20 are getting treatment for diabetes [2]. It is estimated that more than 5% men and more than 4% women in England are found to have diagnosed diabetes. While, 3% menRead MoreDiabetes: Getting to Know it Better1435 Words   |  6 PagesDiabetes has become a prevalent disease, due to its drastic increase in diagnosis since the turn of the 21st century. People of all skin color, social class, or ethnicity can fall prey to this lifelong illness. Individuals that do not have diabetes believe that that they know all the basics and precautions of diabetes, but in all reality many people know very little about what diabetes really is. Understanding what diabetes is, can lead to the knowledge of diabetes association with other diseases